Cortisol is a steroid hormone that is made by the adrenal glands, which are located above the kidneys.
Hormones (like cortisol) are essentially messenger chemicals that coordinate different functions in the body. Cortisol is responsible for stimulating the body’s fight-or-flight response, which occurs when a threat or stress is present.
There are different types of stress, such as:
· Acute stress (sudden danger)
· Chronic stress (long-term frustration or anxiety)
· Traumatic stress
The body will release cortisol in response to any type of stress.
In addition to being the body’s primary stress hormone, cortisol plays an important role in many body systems, including:
· Blood pressure regulation
· Blood sugar control
· Reducing inflammation in the body
· Energy levels and metabolism regulation
· Assisting with memory & the sleep-wake cycle.
There are many factors that influence cortisol levels, including elements of the central nervous system and the adrenal system.
What is cortisol dysregulation?
Cortisol dysregulation, or often seen as HPA axis dysfunction in medical literature, often occurs when someone is under significant stress.
*Note, this is different from Addison’s Disease or Cushing’s Syndrome, which are both medical diagnoses that result from either “flat lined” very low or very high cortisol levels. Addison’s Disease & Cushing’s also have different etiology.
Cortisol dysregulation occurs in that “middle area” where levels are hanging onto normal reference ranges but can still trickle-down to other health issues. Consistently higher or lower cortisol (not meeting an ICD-10 code diagnosis) levels can negatively impact health.
Let’s dissect this. Over time, higher cortisol levels can result in lower cortisol levels. People can progress from phase 1 down to phase 4 and I would succinctly describe it as
Higher cortisol levels:
Think more of the phase 1 as shown above. When the body is under stress, it prioritizes “fighting” off the stressor. This is helpful compensatory mechanism so we can “fight or flight.”
But if the stressor is ongoing or lingers, the consequences of this can be long term as not just an initial safety blanket. Long term, the body continuing to dump out cortisol can alter other normal bodily processes even if there isn’t a diagnosis for it:
Possible symptoms of chronically higher cortisol levels include:
· Anxiety, depression, or panic attacks
· Insomnia
· Weight gain, specifically in the abdominal region
· Brain fog
· Inflammation or pain
· Insulin or blood sugar dysregulation
· Cravings for salty foods
· Hair loss
Lower cortisol levels:
As time passes and a person has been in “fight or flight” for far too longer, cortisol levels can lower. This can result in downregulated sex hormone production (and decreased fertility), electrolyte imbalances cascading to water retention, decrease immunity, worsened fatigue, disrupted sleep, and heightened stress.
Symptoms of lower cortisol include:
· Fatigue or burnout
· Low mood or limited motivation
· Decreased libido
· Orthostatic hypotension (feeling dizzy or weak when standing)
Of course, any of these symptoms can be due to many other root causes, other than just abnormal cortisol levels. This is another reason why getting a medical evaluation is so important. “Test and don’t guess” is an expression I say all the time.
The DUTCH test is one common test and one stone to overturn to gather data on cortisol production and clearance in the body; this test is ordered by many functional nutrition registered dietitians and functional medicine physicians throughout the country.
The more appropriate terminology is cortisol dysregulation which results from communication difficulty along the Hypothalamus-Pituitary-Adrenal (HPA) Axis typically in periods of prolonged stress. Chronic stress keeps your HPA axis constantly engaged.
The HPA Axis is complex and dynamic. To explain further, cortisol is produced in the adrenal glands, which are located on top of the kidneys. However, the hypothalamus and pituitary gland (which are located in the brain) are responsible for managing cortisol levels by instructing the adrenal system to adjust cortisol production as needed in the body.
Been stressed? First, I want to empathize with you. Secondly, what can you do about this:
Medications are not typically prescribed for cortisol dysregulation, but there are plenty of lifestyle changes that CAN help:
General nutrient recommendations for supplements to support adrenal health:
Adaptogenic herbs or “adaptogens” are a class of herbs that help the body “adapt” to stress by modulating cellular sensitivity to stress hormone. Adaptogens such as ashwagandha, ginseng, and rhodiola have a long history of use in traditional Chinese and Ayurvedic medicine. Adaptogen supplements that help both ends of the cortisol dysregulation spectrum. As always, check with your healthcare team before starting anything as contraindications for you may exist.
Get my adrenal support protocol (with 15% off an free shipping) with dosing, instructions and general education handouts.
Looking for individualized nutrition guidance?
If you are questioning that you have a problem with cortisol dysregulation and want help navigating it, there are things you can do to feel better.
I heavily support (and utilize) functional nutrition in my practice. Sometimes, medical management and/or behavioral health experts are essential and I refer out when needed.
If you are interested in an individualized nutrition consultation, I offer telehealth nutrition packages. I often utilize the DUTCH test as part of my nutrition assessment.
Ready to get started? Then go ahead, schedule your package now!
Warmly,
Katie Driessens, RD,LDN, CDCES, CGN
*This blog on the Dietetics with Driessens LLC website is maintained by Katie Driessens, Owner. All opinions are her own and for general educational purposes. Advertising, affiliate links or other forms of compensation are within this website and a small commission is earned for sales made through these links (with no extra cost to you) that help cover costs of running a small business. Products and services listed are prior carefully created and/or evaluated to ensure that they are accurate and supported by scientific evidence. Items or programs that are endorsed are based on Katie’s professional experience and expertise & are worthy of such endorsement. Dietetics with Driessens LLC assumes no responsibility or liability for damage or injury to persons arising from any use of any product, information, or opinion contained in the information of this blog, none of which is to be considered personal medical advice. By viewing, using, and shopping from this website, you agree to release Dietetics with Driessens LLC from full responsibility to the fullest extent allowed by law. Products & Services sold are not intended to diagnose or cure any disease. Consult your physician before beginning any exercise, supplement, meal plan or program. Thank you!
August 11, 2025
Be the first to comment